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In order to determine whether club cells in the small airway constitute a homogenous or heterogenous population and to determine whether cigarette smoking caused changes to one or more club cell subtypes, SAE of normal nonsmoker and healthy smoker lungs were sampled by bronchoscopy and brushing, and single cell transcriptomics was utilized to identify and characterize heterogeneity in the SCGB1A1 + club cell population

In making himself the most distinctive face and voice of his mightiest directorial project, Lynch made himself the icon of his own artand, indeed, a prime emblem for the cinema of his time

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