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Esta molcula es un antioxidante celular esencial, que est presente en todos los rganos y tejidos, especialmente en el hgado, donde se encuentran las mayores concentraciones (1)(4-6)

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2 The global burden of IHD: incidence, prevalence, and mortality Cardiovascular diseases account for 32% of all global deaths, with an estimated 19.8 million deaths annually, and 85% of these deaths are attributed to IHD and stroke (WHO, 2017)

Several studies of HCC cells have shown that inhibition of NFE2L2 expression can increase the anticancer activity of the chemicals erastin and sorafenib, with inhibition of NFE2L2 inducing ferroptosis and killing HCC cells (64)