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Magnetic resonance spectroscopy reveals mitochondrial dysfunction in amyotrophic lateral sclerosis

The two segments on the human CENP-C (CENP-C 426537 and CENP-C 737-359 ) recognize and bind the CENP-A nucleosome by interlocking with its C-terminal tail, which is exposed on the surface of the nucleosome and the acidic patch on histone H2A that is also exposed on the surface of the nucleosome