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The ability to counteract side effects while leaving desired effects intact is a holy grail of modern medical research as it would improve therapeutic benefits for a number of drugs

Therefore, improving the metabolic status and effector function of T cells with corresponding checkpoint inhibitors is effective, as has been confirmed in some studies [367, 368]

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Exposure to LPS has been shown to increase reactive oxygen species (ROS) production [60] and lead to metabolic reprogramming from oxidative phosphorylation to glycolysis, particularly in microglia, the primary innate immune cells in the brain [61]