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doi: 10.1021/jf503257w

Metformin inhibits the production of reactive oxygen species from NADH:Ubiquinone Oxidoreductase to limit induction of Interleukin-1 (IL-1) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

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Combined neutralization of IL-22 and IL-6 reduced but did not abrogate TIL supernatant-induced STAT3 activation and CRC cell proliferation, probably because of the presence of additional STAT3-activating cytokines/factors in TIL-derived supernatants (for example, IL-11 or EGF)