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This pathway activation results in increased endothelial nitric oxide synthase (eNOS) activity, promoting vasodilation and new blood vessel formation

Pathogenesis Arises from terminal ductule epithelial cells (canal of Hering cells) spontaneously, following liver infections, and secondary to hepatotoxic injury

Mari et al., 2009), which in the liver account for about one third of the total Gpx activity ( 2 O 2 and has been classically believed to be the major H 2 O 2 reducing enzyme

Glutathione exists in two primary states within the cell: Reduced glutathione (GSH): The active, antioxidant form Oxidized glutathione (GSSG): The spent form, converted back to GSH by the enzyme glutathione reductase using NADPH Under healthy physiological conditions, more than 98% of cellular glutathione exists in the reduced (active) form