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Moreover, hydroxyl radicals generated from the reaction between free ferrous iron and hydrogen peroxide can oxidize PUFAs by capturing hydrogen atoms at the diallyl site of PUFAs, representing an enzyme-independent autoxidation[29]

Folia Histochem Cytobiol 2005

For instance, Salvianolic acid B was shown to attenuate paraquat-induced pulmonary fibrosis by restoring the Nrf2/NOX4 redox balance, where Nrf2 activation suppressed NOX4 expression and downstream TGF-1/Smad3 signaling ( S