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To this fact it must be added lipid and glucose dysregulation are common in BD patients, even before the diagnosis and treatment [247] and atypical antipsychotics can worsen these alterations

The production of inflammatory cytokines IL-1, IL-6, and TNF- in the medium was also significantly increased in hepatocytes exposed to fructose, while IL-6 and TNF- levels in FFr-treated cells were higher than in FFA cells ( Fig