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Strikingly, they found that in the long-lived mutants, prohibitin depletion correlates with lower fat levels, reduced mitochondria content, and increased ATP production, whereas in wild-type worms, prohibitin depletion results in only a slight decrease in fat content, an increase in mitochondrial level, and no change in ATP synthesis

Chaudhary A, Wakhlu A, Mittal N, Misra S, Mehrotra D, Wakhlu AK (Jan

These pathological changes were largely prevented by reducing immune cell infiltration using natalizumab, accompanied by reduced motor neuron degeneration, delayed onset of paralysis, and prolonged survival

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