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Furthermore, in patients with HCV-related chronic liver disease, levels of taurine-conjugated BAs strongly correlated with increased hepatic S1PR2 expression, markers of inflammation (NLRP3 inflammasome, NF-B pathway genes), and liver disease severity, suggesting a pathological role for the Tau-BA-S1PR2 axis in hepatic inflammation (104)

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In LTB PDM/DM combined, there was a decrease in T cells expressing cytokines, cytotoxicity, and other immune markers as well as elevated levels of cytokines in supernatants (165)