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+ Bedtime routine: Create a calm routine before bed (e.g., reading, light music, meditation) to help your body and mind wind down

Excessive ROS levels may impair the hypoxia-inducible factor (HIF)-1/BNIP3-mediated mitophagy pathway, thereby weakening mitophagy and exacerbating mitochondrial dysfunction [114]

While several studies have investigated various oxidative stress markers for prenatal screening of chromosomal abnormalities [3, 26], the potential role of these specific antioxidant markers in Down syndrome detection has remained largely unexplored

The clock hour you choose is irrelevant as long as it supports adherence