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1 Introduction Amyloids are non-native aggregates formed from cytosolic or membrane associated proteins in neurons which have defined physiological functions but transform into soluble and toxic fibrillar entities under poorly understood altered conditions

It penetrates cell membranes and interacts directly with DNA

In this study, we investigated the effects of dysregulated glutathione homeostasis, a principal feature of oxidative stress, on TNF-induced hepatotoxicity and its mechanistic implications in NAFLD progression

endogenous H 2 O 2 concentrations may be subthreshold, and excessive GSH can scavenge ROS and attenuate efficacy 265,266