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Adjuvant Chemotherapy for Stage II Colon Cancer (Peer-Reviewed Review)

However, the bulk degradation of PLGA may cause localized inflammation due to acidic products formed, especially in poorly buffered systems 97

Most available mTOR inhibitors that have been rigorously tested for clinical uses are rapamycin derivatives, and the majority of these tests have been focused on their anti-proliferation effects for cancer treatment (84)

Since the cellular synthesis of glutathione is ATP-dependent, decreased ETC activity also undermines glutathione synthesis, further exacerbating oxidative stress in a vicious cycle [8]