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doi: 10.1016/j.immuni.2015.04.021

Studies suggest lactic acid from these delivery systems may modulate macrophage infiltration and upregulate TGF- expression, potentially facilitating endogenous collagen regeneration and sustained tissue remodeling

Fideles, S

In preclinical rat models of STZ-induced DN, PW507 demonstrated significant efficacy in alleviating mechanical allodynia and thermal hyperalgesia following acute and chronic (2-week) administration without inducing tolerance and visual evidence of toxicity