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INTRODUCTION Vitamin B12 is essential for DNA synthesis, red blood cell formation, and neurologic function[] and is also involved in the metabolism of fat and carbohydrate.[] The clinical manifestations of vitamin B12 deficiency are the effects of depletion on multiple systems, and their severity varies greatly

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reported that CircXRN2 can inhibit the degradation of LATS1, thereby activating the Hippo signaling pathway, inhibiting glycolysis and lactate production, subsequently suppressing H3K18la, and ultimately inhibiting the progression of bladder cancer mediated by histone lactylation [35]