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The cGAS-STING pathway is a major cytosolic DNA-sensing pathway, where cGAS detects foreign DNA and synthesizes cyclic GMP-AMP, which then binds to and activates STING

It encourages the production of telomerase, an enzyme that repairs and extends telomeres, supporting healthier cell replication

Cyclin D1 promotes the progression of the G1S phase, and tamoxifen can reduce the expression of cyclin D1, which is highly expressed in drug-resistant cells (Viedma-Rodriguez et al., 2014)

He contributed to our results, along with many Wirecutter colleagues both inside and outside of our editorial team who participated in the initial round of testing