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Girldez-Prez, R

(134) found that after EODF intervention, differentially expressed genes (DEGs) were enriched and associated with various biological events, including immune-inflammatory responses, cell differentiation, protein modification, neurogenesis, and apoptosis

In this study, SFN treatment mitigated the proteinuria and fibrosis seen in the diabetic mice, and also attenuated the kidney levels of profibrotic mediators (TGF- and connective tissue growth factor), inflammatory mediators [plasminogen activator inhibitor -1 (PAI-1) and vascular cell adhesion molecule-1 (VCAM-1)], and indicators of oxidation (3-nitrotyrosine and 4-hydroxy-2-noneal) [104]