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TMEM164 may play an important role only in certain cellular contexts because ferroptosis resistance after TMEM164 deletion has been associated with an increase in MUFA-containing ePEs, while the ferroptosis rates in cells with other types of phospholipid species were unaffected by TMEM164 deficiency, as indicated because they do not show an accumulation of MUFA-ePEs 136

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Researchers measured mtDNA copy number in single oocytes and found modest increases post mitochondrial peptide treatment in some animal studies

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