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According to a 2021 literature review spanning over 40 years of research, hCG therapy is considered the top choice for patients suffering from secondary hypogonadism because it triggers the body to produce testosterone and sperm without side effects on fertility, such as those seen in testosterone replacement therapy

This may also allow the more energy-efficient MAS to shuttle cytoplasmic NADH reducing equivalents to the mitochondrial matrix for ATP synthesis when the cytoplasmic [NAD + ]/[NADH] is more oxidized

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