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When AhR was bound to its agonist, AHR was dissociated from the protein complex and translocated to the nucleus, where it interacted with aryl hydrocarbon receptor nuclear transporter (ARNT) to form a dimer, and activated transcription of target genes by binding to specific enhancer sequences in the regulatory regions of target genes, such as the aryl hydrocarbon receptor response element on the cytochrome P450 Family 1 subfamily B member 1 (CYP1B1) promoter (78)

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Following their absorption from the colon, acetate has been estimated to account for about 10% of total human energy expenditure 247,248

In addition to experimental techniques, computational models were also developed to study the role of cytosolic NADH/NAD+ ratio on the mitochondrial NADH/NAD + ratio in various disease states, including ischemia reperfusion and in cancer (91)