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TMAO can aggravate acute electrical remodeling in AF models and enhance atrial electrophysiological instability in normal canines by enhancing autonomic remodeling and boosting the p65 NF-B signaling pathway [84]

Gut microbes consume acylcarnitines in a category-specific pattern, suggesting that the metabolic requirements and utilization efficiency of these compounds vary among bacterial species [231]

In the present study, we extended our previous research by analyzing the protective effect of l-Carnitine on autophagy-associated apoptosis and its underlying molecular mechanisms

In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)