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One of the pathophysiological mechanisms involved in acute tissue injury is the activation of the systemic inflammatory response due to the contact of blood with non-endothelial surfaces, leading to the release of various inflammatory and coagulation factors and, ultimately, to the activation of effector cells ( Next, we describe the process of neutrophil activation and its contribution to acute organ injury with a further understanding of the pathophysiological mechanisms of acute organ injury in ECMO

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