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A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment

With rigorous preclinical and clinical evaluation, PLGA nanoparticle systems hold strong potential for successful translation from bench to bedside

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The second, third, and fourth group received an oral dose of Sildenafil (1.48 mg/kg), Tadalafil (0.285 mg/kg), and Vardenafil (0.285 mg/kg) respectively, three times per week for 12 weeks