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Systemic exposure to the CYP3A-mediated metabolites 1-hydroxymidazolam and 4-hydroxymidazolam also increased (AUC inf , ~1827%) but by a smaller magnitude compared with midazolam

In addition, hydrochlorothiazide, bumetanide and furosemide were also consistently linked to altered blood glucose and impaired glucose tolerance in a variety of animal models (Foy, 1967

Among these, the most studied and understood alternative is the DEHA or di(Ethylhexyl) adipate