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A.HuJ.et al (2015)

Eur J Epidemiol 32(5):377389 Tradtrantip L et al (2017) Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica

CKD is associated with changes in the intestinal microbiota

The first one, setmelanotide, was approved in 2020, and it is used in patients with POMC, PCSK1, or leptin receptor (LEPR) deficiencies, which result in insufficient activation of the MC4R and, consequently, cause excessive appetite and severe obesity developing in early childhood