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National Institute for Biological Standards and Control

CagriSema is a fixed-dose combination therapy comprising two molecules administered together in a single once-weekly subcutaneous injection: semaglutide 2.4 mg, a glucagon-like peptide-1 (GLP-1) receptor agonist already approved for weight management as Wegovy, and cagrilintide 2.4 mg, a long-acting analogue of amylin, a hormone involved in appetite regulation and satiety signalling

In addition, a 2-year RCT of an older subpopulation in a primary care setting demonstrated similar efficacy of orlistat in both older and younger adults of around 8% [106]

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