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"It is particularly prevalent in high rainfall areas (450mm rain per year), where improved, irrigated or fertilised pastures can grow rapidly, such as a spring flush." Symptoms of clinical deficiency in young livestock include scouring

Oral absorption is considered too undependable to rely on in patients with pernicious anemia or other conditions resulting in malabsorption of vitamin B12

We highlight key E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) that modulate the abundance of core clock components and their downstream effectors and discuss how disruptions in these processes can lead to circadian misalignment and disease