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Although generally safe, injections should be used with caution in people with a history of allergic reactions to cobalamin or in people with Leber's disease (hereditary optic neuropathy), as B12 may worsen the condition

This mini review summarizes neurotrophin biology relevant to bone sarcoma, delineates mechanisms by which these pathways reprogram immune and stromal compartments, and evaluates therapeutic strategies ranging from ligand/receptor blockade to clinically available TRK inhibitors, with the objective of defining tractable approaches to restore immune competence in this disease

Sickle Cell Anemia Pernicious Anemia Pernicious anemia, once it manifests, will require treatment for the duration of ones life, yet treatment is well tolerated and the disorder should not cause significant hardship

I also want to note the dosages used here the supplementation is around 110 mg of B12 when reactions have been reported in these case studies