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Apoptosis analysis and proliferating cell nuclear antigen immunohistochemistry Mice were sacrificed 1, 3, 4, 6 or 8 days after 5-FU injection, and intestinal tissue samples were collected, fixed with 4% paraformaldehyde overnight, and embedded in paraffin

Cell treatment conditions NUGC-4 and MKN-45 cells were exposed to the following conditions: control, transfected with empty lentivirus for 48 h

(Image source: Nature.com) Though bats are likely the original source of SARS-CoV-2, several pieces of evidence cast doubt on pangolins as an intermediate host: 1) despite the high similarity between SARS-CoV-2 and pangolin coronavirus RBDs, their overall genome similarity is relatively low (~90%) [4]