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A number of high-throughput screening studies have identified antagonists of the cGAS-STING pathway which have been demonstrated to either inhibit cGAS (103) or STING though competitively binding at the substrate binding sites (104) or induce conformation change (105) ( Figure 2B )

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We calibrate our model using time-resolved lineage data and deep mutational scanning profiles from in vivo experiments, ensuring that our theoretical predictions are grounded in realistic biophysical parameters