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It reduces shelf life from 28 days to under 72 hours and increases contamination risk with repeated needle entry

the lipid vesicles can be formed by hydration in an aqueous buffer and sized using any of the methods described above prior to addition of the nucleic acid

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Over 42 days, the ethanol group received 20% ethanol in their drinking water, while losartan was administered intraperitoneally at doses of 1 mg/kg and 3 mg/kg to the treatment groups.The results demonstrated that losartan significantly reduced oxidative stress markers, evidenced by decreased levels of malondialdehyde and increased total thiol levels in renal tissues