ORCID: Affiliation: 4 Basic Research Division, Instituto Nacional de Cancerologa, Mexico City 14080, Mexico ORCID: Affiliation: 5 Laboratory of Translational Cardiology, Translational Medicine Laboratory, Instituto de Investigaciones Biomdicas/Universidad Nacional Autnoma de Mxico, Instituto Nacional de Cardiologa Ignacio Chvez, Mexico City 14080, Mexico ORCID: Affiliation: 5 Laboratory of Translational Cardiology, Translational Medicine Laboratory, Instituto de Investigaciones Biomdicas/Universidad Nacional Autnoma de Mxico, Instituto Nacional de Cardiologa Ignacio Chvez, Mexico City 14080, Mexico ORCID: Affiliation: 1 Experimental and Translational Medicine, Health Sciences Department, Universidad Autnoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico ORCID: Affiliation: 1 Experimental and Translational Medicine, Health Sciences Department, Universidad Autnoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico ORCID: Affiliation: 1 Experimental and Translational Medicine, Health Sciences Department, Universidad Autnoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico ORCID: Affiliation: 1 Experimental and Translational Medicine, Health Sciences Department, Universidad Autnoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico ORCID: Affiliation: 1 Experimental and Translational Medicine, Health Sciences Department, Universidad Autnoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico ORCID: Affiliation: 1 Experimental and Translational Medicine, Health Sciences Department, Universidad Autnoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico Email: [email protected] ORCID: Affiliation: 1 Experimental and Translational Medicine, Health Sciences Department, Universidad Autnoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico Email: [email protected] ORCID: Explor Dig Dis
The logic is that sustained exposure over a longer window may matter more than peak concentration particularly for an epigenetic mechanism that operates through gene expression changes, which take time to manifest
Patient Characteristics The GSH levels in 41 OC tissues were measured
The medication mechanism may still be appropriate, but vitamin D deficiency, zinc/B6 depletion, copper accumulation, elevated SAH, inflammation, poor sleep, hormonal change, toxic burden or medication interactions may have altered the biochemical environment
