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A small fraction of the observed variability in lung function and symptom responsiveness can be explained by differences in age and in body mass index (BMI) with young adults (teens to thirties) and those with high BMI being much more responsive than older adults (fifties to eighties) and those with low BMI

and oxygen saturation (SaO 2 ), 99% on room air

Moreover, robust evidence regarding long-term efficacy and cost-effectiveness, gaps in interdisciplinary collaboration, and challenges related to patient adherence and health equity collectively constrain the real-world applicability of this approach

doi: 10.1371/journal.pone.0243144 97