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Description

Pulmonary diseases and the liver

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Glucocorticoids can suppress glycolysis by blocking the transcriptional and post-translational effects of hypoxia-inducible factor 1 (HIF-1) in macrophages, while promoting glutamine metabolism to enhance TCA cycle flux and succinate metabolism, thereby preventing intracellular succinate accumulation and facilitating the conversion of macrophages from the M1 to the M2 phenotype (112, 113)

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Immune Dysregulation: Damaged mitochondria activate inflammatory pathways, including NLRP3 inflammasome and cGAS-STING, worsening immune imbalances

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(2024, December 4)

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