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doi: 10.1038/s41423-024-01220-3 117 CaoQWangYChenJWangRChenTGlossBet al

The animal experiments were accomplished in compliance with ethical standards

Let's try not to put too much scientific jargon in here

This system uses TrxR to reduce Trx with NADPH, which maintains the reduced state of intracellular proteins through disulfide bond exchange, thereby maintaining cell survival in the event of a GPX4 functional defect (161)