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29 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Reversible metabolism via enterohepatic cycling Liu and Smith, Current Drug Metabolism, 2006EHC is not irreversible elimination, thus it acts as a distribution compartment for some drugs

Statistical analysis was performed using the method proposed by Love et al

Indeed, MTHFR variants are associated with increased risk for many diseases, including depression, fertility issues, insomnia, and thyroid conditions ( 3 )