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Description

Glioblastoma relapses show increased markers of vulnerability to ferroptosis

It suggested that GD activates Nrf2 signaling pathway to increase HO-1 expression to regulate the expression of related proteins [133]

Many mechanisms have been proposed to explain MDR, such as the decrease in intracellular drug concentrations due to efflux pump induction, the mutation of drug targets, the upregulated metabolic detoxification, and the enhanced DNA damage repair function [63]