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Research uses this combination to investigate peptide driven effects on extracellular matrix remodeling, cell migration, cytoskeletal organization, and gene expression patterns related to tissue structure and repair, with all applications restricted to laboratory research use only

To diagnose fibromyalgia, the following are required: The presence of generalized pain, for which there is no other explanation, lasting at least three months and affecting at least four of five established body regions: the left upper, right upper, left lower, right lower, and axial (encompassing the head, neck, chest, and back) regions

doi: 10.1186/1472-6882-13-355 CrossRef Google Scholar View reference in article 62 KennedyD

These results are backed up by the finding of a strong increase of the concentration of Pycnogenol s metabolites and components in the synovial fluid, surrounding articular cartilage in the joints in osteoarthritis patients (71, 72)