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However, nicotine also acts as an agonist on nicotinic acetylcholine receptors (nAChRs), which play a key role in regulating neurotransmitter release, neuronal excitability, and cognition ( Nicotine has neuroprotective capabilities largely attributed to its ability to initiate protective signaling transduction that enhances dopamine release and reduces neurotoxicity

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What people dont often realize is that fatigue may be related to more than sleep deprivation

Fujitani K, Ajani JA, Crane CH, Feig BW, Pisters PW, Janjan N, Walsh GL, Swisher SG, Vaporciyan AA, Rice D, Welch A, Baker J, Faust J, Mansfield PF