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The criteria of bronchial and bronchiolar epithelial degeneration and necrosis, luminal inflammation, interstitial and alveolar edema, hemorrhage, inflammation, perivascular inflammation and vascular congestion were graded as follows: (0) normal histology, (1) mild 50% tissue damage

This indicates that ERS triggers ferroptosis-associated EMT progression via the XBP1-HRD1-NRF2 pathway (88).Various anti-solid tumor drugs can increase intracellular ROS and Ca 2+ , both of which can induce ERS

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It is noteworthy that SOD1 G93A astrocyte-induced motor neuron death seems in part mediated by host microglial activation [80]