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J Clin Endocrinol Metab 70:519527 Bianda T, Hussain MA, Glatz Y, Bouillon R, Froesch ER, Schmid C (1997) Effects of short-term insulin-like growth factor-I or growth hormone treatment on bone turnover, renal phosphate reabsorption and 1,25 dihydroxyvitamin D3 production in healthy man

The greater concern is wasted treatment time and cost

In a bladder cancer cell metastasis model, NNMT knockout significantly reduced the migration ability of bladder cancer cells, and the product, as an NNMT inhibitor, achieved similar effects