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Limited data suggests that the anti-migraine therapies amitriptyline and cyproheptadine, and the mitochondrial-targeted cofactors co-enzyme Q10 and L-carnitine, have efficacy in episode prophylaxis

Injectables are commonly recommended because of their effectiveness

In neuromyelitis optica, pathogenic autoantibodies target AQP4 by binding to orthogonal arrays of particles, thereby disrupting astrocyte function [415, 416]

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