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Pinnagoda K, Larsson HM, Vythilingam G, Vardar E, Engelhardt EM, Thambidorai RC, et al

Cell Mol Gastroenterol Hepatol 9:465483 Erny D, de Angelis ALH, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Utermohlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A, Staeheli P, Stecher B, Amit I, Prinz M (2015) Host microbiota constantly control maturation and function of microglia in the CNS

Both peptides may also affect cytokine expression and reduce inflammatory processes, and Epitalon additionally shows anti-cancer effects in animal studies

Administration of malvidin-3- O -glucoside was found to attenuate the depressive-like behavior through its ability to cross the BBB and upregulation of Rac1 expression in the nucleus accumbens (Wang et al., 2018), a protein whose depletion contributes to the disturbed synaptic structure in depression (Golden et al., 2013)