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[4] The FCTC, one of the most quickly ratified treaties in United Nations history, [5] is a supranational agreement that seeks "to protect present and future generations from the devastating health, social, environmental and economic consequences of tobacco consumption and exposure to tobacco smoke" by enacting a set of universal standards stating the dangers of tobacco and limiting its use in all forms worldwide

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Moreover, user behaviors such as frequency of use, puffing patterns, motivation to use, and e-cigarette dependence may also result in individual variations in physiological responses