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Tirzepatide (development code LY3298176) is a single engineered peptide a fatty-acid-modified 39-amino-acid molecule that acts as a dual agonist at two incretin receptors: the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor

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The study characterized the degradation kinetics of AOD9604 in biological matrices and identified the specific cleavage products generated by endogenous proteases