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Skin Firmness, Hydration, and a Refreshed Complexion Collagen plays a major role in the skin's ability to retain moisture and maintain skin firmness

The cells were cultured in DMEM/F-12 medium (11320033, Gibco, USA) supplemented with 5% horse serum and 2.5% fetal bovine serum at 37C under an atmosphere of 5% CO 2

As a D-amino acid peptide, FOXO4-DRI is costly to synthesize, and a wrong amino acid at the binding site can sharply cut activity

Taken together, these results suggest that nuclear localization of FOXO4 may contribute to Leydig cell senescence and the downregulation of testosterone synthesis