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E-cigarette and cannabis use are harmful to adolescents brain development, can lead to addiction, and are linked to depression and other mental health problems

This is not only because smokers compensate by increasing inhalation leaving their smoke intake relatively unchanged, but also because a point is reached where reduced nicotine delivery meets with reduced consumer acceptance.[29] Dr Russells observations aside, there was little scientific support behind the idea that if nicotine could be successfully liberated from tobacco, the result could be a dramatic improvement in public health not least because substantial numbers of doctors believed nicotine caused cancer

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