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10.4268/cjcmm20161406 16 ChenY.LiH.LiuN.FengD.WuW.GuK.et al

PHARMACOTHERAPIES TARGETING ENDOTHELIAL DYSFUNCTION IN ATHEROSCLEROSIS Accumulating evidence suggests that pharmacological agents-ranging from approved therapeutics to investigational compounds, with diverse chemical structures and mechanisms of action-can modulate endothelial function

The role of oxidative stress in AD pathogenesis is well established with substantial evidence demonstrating evidence of ROS-mediated injury and free radical damage to key intracellular targets such as DNA or mitochondria in AD brains (Fig