rj reynolds tobacco company king nc R. J. 1850-1918 (J-72) R. J. Reynolds - Wikipedia

The researchers said nicotine altered levels of the brain chemical dopamine, which has already been implicated in the psychosis

Chapter 36 Caffeine and Related Nonprescription Sympathomimetics

The inclusion of the health warning in advertising may have had a similarly reassuring effect on the publishers of other newspapers or magazines, who, while not going as far as to refuse cigarette advertising at the time the Cigarette Smoking Act was passed, had perhaps felt themselves under pressure from public-health groups or from this or that senator concerned about the relationship between cigarette promotion, the cigarette habit, and the high incidence of certain diseases among smokers

Thats the reason why beekeepers always have bee smoker in their hand and with few puffs of smoke bees entire bee colony will calm down