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Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

No binder or antioxidant regimen will produce lasting mycotoxin reduction in someone returning nightly to a water-damaged building

By categorizing patients into hyper-oxidative, reductive, or mixed phenotypes, clinicians can tailor interventions, avoid the pitfalls of empirical antioxidant therapy, and improve ART outcomes